abstract：:The functions of nerve growth factor (NGF) in skeletal muscles physiology and pathology are not clear and call for an updated investigation. To achieve this goal we sought to investigate NGF-induced ERK1/2 phosphorylation and its role in the C2C12 skeletal muscle myoblasts and myotubes. RT-PCR and western blotting exp...

journal_title：Cellular signalling

authors： Ettinger K,Lecht S,Arien-Zakay H,Cohen G,Aga-Mizrachi S,Yanay N,Saragovi HU,Nedev H,Marcinkiewicz C,Nevo Y,Lazarovici P

更新日期：2012-12-01 00:00:00

abstract：:Protein phosphatases play a key role in balancing the cellular responses to the transforming growth factor-β (TGFβ) signals. Several protein phosphatases have been attributed roles in the regulation of the TGFβ pathway. Among these, PPM1A is the only phosphatase reported to dephosphorylate SMAD2/3 in the nucleus. Howe...

journal_title：Cellular signalling

authors： Bruce DL,Macartney T,Yong W,Shou W,Sapkota GP

更新日期：2012-11-01 00:00:00

abstract：:β-Adrenergic receptors (βAR) and D(2)-like dopamine receptors (which include D(2)-, D(3)- and D(4)-dopamine receptors) activate G(s) and G(i), the stimulatory and inhibitory heterotrimeric G proteins, respectively, which in turn regulate the activity of adenylyl cyclase (AC). β(2)-Adrenergic receptors (β(2)AR) and D(4...

journal_title：Cellular signalling

authors： Rebois RV,Maki K,Meeks JA,Fishman PH,Hébert TE,Northup JK

更新日期：2012-11-01 00:00:00

abstract：:The constitutively activated mutation (V617F) of tyrosine kinase Janus kinase 2 (JAK2) is found in the majority of patients with myeloproliferative neoplasms (MPNs). The development of a novel chemical compound to suppress JAK2 V617F mutant-induced onset of MPNs and clarification of the signaling cascade downstream of...

journal_title：Cellular signalling

authors： Funakoshi-Tago M,Nagata T,Tago K,Tsukada M,Tanaka K,Nakamura S,Mashino T,Kasahara T

更新日期：2012-11-01 00:00:00

abstract：:Major diseases such as cardiovascular diseases, rheumatoid arthritis, diabetes, obesity and tumor growth are known to involve inflammation. Inflammatory molecules such as MCP-1, TNF-α, IL-1β and IL-8 are known to promote angiogenesis. MCP-induced protein (MCPIP), originally discovered as a novel zinc finger protein in...

journal_title：Cellular signalling

authors： Roy A,Kolattukudy PE

更新日期：2012-11-01 00:00:00

abstract：:15-lipoxygenase (15-LO) is known to play an important role in chronic pulmonary hypertension. Accumulating evidence for its down-stream participants in the vasoconstriction and remodeling processes of pulmonary arteries, while how hypoxia regulates 15-LO/15-hydroxyeicosatetraenoic acid (15-HETE) to mediate hypoxic pul...

journal_title：Cellular signalling

authors： Zhang L,Ma J,Shen T,Wang S,Ma C,Liu Y,Ran Y,Wang L,Liu L,Zhu D

更新日期：2012-10-01 00:00:00

abstract：:Binding of urokinase-type plasminogen activator (uPA) to its receptor, uPAR, in estrogen receptor-α (ERα) expressing breast cancer cells, transiently activates ERK downstream of FAK, Src family kinases, and H-Ras. Herein, we show that when uPAR is over-expressed, in two separate ERα-positive breast cancer cell lines, ...

journal_title：Cellular signalling

authors： Eastman BM,Jo M,Webb DL,Takimoto S,Gonias SL

更新日期：2012-09-01 00:00:00

abstract：:Aurora B kinase forms the enzymatic core of the Chromosomal Passenger Complex (CPC) and is a master regulator of mitosis. Understanding the regulation of Aurora B is critical to illuminate its role in mitosis. INCENP, Survivin and Borealin have all been known to promote Aurora B activation. In this study, we have iden...

journal_title：Cellular signalling

authors： Iyer J,Tsai MY

更新日期：2012-08-01 00:00:00

abstract：:Recent studies have shown DAPk as a molecular modulator induced by the second messenger, responsible for controlling cell destiny decisions, but the detailed mechanism mediating the role of DAPk1 during cell death is still not fully understood. In this present report, we attempted to characterize the effects of TNF-α ...

journal_title：Cellular signalling

authors： Yoo HJ,Byun HJ,Kim BR,Lee KH,Park SY,Rho SB

更新日期：2012-07-01 00:00:00

abstract：:The combination of curcumin and TRAIL and their role in enhancing apoptotic cell death has been reported by many studies. However, the exact molecular mechanism of apoptosis mediated by curcumin and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is not yet completely understood. In this study, we obse...

journal_title：Cellular signalling

authors： Kim J,Kim SY,Kang S,Yoon HR,Sun BK,Kang D,Kim JH,Song JJ

更新日期：2012-07-01 00:00:00

abstract：:Macrophages take up oxidized low density lipoprotein (oxLDL) after being exposed to it in the blood vessels. oxLDL transforms macrophages into foam cells, which are a hallmark of atherosclerosis. The effects that oxLDL have on the inflammatory responses of foam cells are not clear. Here, we investigated how oxLDL modu...

journal_title：Cellular signalling

authors： Min KJ,Cho KH,Kwon TK

更新日期：2012-06-01 00:00:00

abstract：:This study examines the role of the unconventional gaseous signaling molecule nitric oxide (NO) on the regulation of heart rate in the Vietnamese stick insect, Baculum extradentatum. Using nicotinamide dinucleotide hydrogen phosphate (NADPH)-diaphorase histochemistry, as well as immunohistochemistry and Western blotti...

journal_title：Cellular signalling

authors： da Silva R,da Silva SR,Lange AB

更新日期：2012-06-01 00:00:00

abstract：:Protease-activated receptor 1 (PAR1) is an unusual GPCR that interacts with multiple G protein subfamilies (G(q/11), G(i/o), and G(12/13)) and their linked signaling pathways to regulate a broad range of pathophysiological processes. However, the molecular mechanisms whereby PAR1 interacts with multiple G proteins are...

journal_title：Cellular signalling

authors： McCoy KL,Gyoneva S,Vellano CP,Smrcka AV,Traynelis SF,Hepler JR

更新日期：2012-06-01 00:00:00

abstract：:AMP-activated protein kinase (AMPK), an important regulator of energy homeostasis, is known to be activated during T cell activation. T cell activation by T cell receptor (TCR) engagement or its pharmacological mimics, PMA plus ionomycin (PMA/Io), induces immunomodulatory FasL and cyclooxygenase-2 (COX-2) expression. ...

journal_title：Cellular signalling

authors： Lee JY,Choi AY,Oh YT,Choe W,Yeo EJ,Ha J,Kang I

更新日期：2012-06-01 00:00:00

abstract：:The BRCA1 gene codes for a protein involved in the DNA double strand break (DDSB) repair. Alongside the dominant full-length splicing form of BRCA1, numerous endogenously expressed alternative splicing variants of unknown significance have been described in various tissues. Some of them retain the original BRCA1 readi...

journal_title：Cellular signalling

authors： Sevcik J,Falk M,Kleiblova P,Lhota F,Stefancikova L,Janatova M,Weiterova L,Lukasova E,Kozubek S,Pohlreich P,Kleibl Z

更新日期：2012-05-01 00:00:00

abstract：:Heat shock protein 90 (Hsp90) serves to stabilise and correctly fold multiple significant client proteins associated with cell proliferation and cell survival. However, little is known about the Hsp90 client proteins that regulate cell metabolism. Here, we describe a unique ability of Hsp90 to regulate the stability a...

journal_title：Cellular signalling

authors： Zhang L,Yi Y,Guo Q,Sun Y,Ma S,Xiao S,Geng J,Zheng Z,Song S

更新日期：2012-04-01 00:00:00

abstract：:Wnt proteins are secreted glycoproteins that bind to the N-terminal extra-cellular cysteine-rich domain of the Frizzled (Fzd) receptor family. The Fzd receptors can respond to Wnt proteins in the presence of Wnt co-receptors to activate the canonical and non-canonical Wnt pathways. Recent studies indicated that, among...

journal_title：Cellular signalling

authors： King TD,Zhang W,Suto MJ,Li Y

更新日期：2012-04-01 00:00:00

abstract：:Signal transducer and activator of transcription 6 (Stat6) is critical in Th2 polarization of immune cells and active Stat6 activity has been suggested in anti-tumor immunity in animal models. The present study aims at investigating the impact of natural Stat6 activity on tumor microenvironment in human colorectal can...

journal_title：Cellular signalling

authors： Li BH,Xu SB,Li F,Zou XG,Saimaiti A,Simayi D,Wang YH,Zhang Y,Yuan J,Zhang WJ

更新日期：2012-03-01 00:00:00

abstract：:Previously, we demonstrated that the transient receptor potential vanilloid 4 (TRPV4) cation channel, a member of the TRP vanilloid subfamily, is one of the serum glucocorticoid-induced protein kinase1 (SGK1) authentic substrate proteins, and that the Ser 824 residue of TRPV4 is phosphorylated by SGK1. In this study, ...

journal_title：Cellular signalling

authors： Shin SH,Lee EJ,Hyun S,Chun J,Kim Y,Kang SS

更新日期：2012-03-01 00:00:00

abstract：:The dual-specificity mitogen-activated protein kinase (MAPK) phosphatase-1 (MKP-1) inactivates MAP kinases by dephosphorylation. Here we show that the proinflammatory cytokine interleukin (IL)-17A induces adult mouse primary cardiac fibroblast (CF) proliferation and migration via IL-17 receptor A//IL-17 receptor C-dep...

journal_title：Cellular signalling

authors： Valente AJ,Yoshida T,Gardner JD,Somanna N,Delafontaine P,Chandrasekar B

更新日期：2012-02-01 00:00:00

abstract：:Nephrin, an important structural and signal molecule of podocyte slit-diaphragm (SD), has been suggested to contribute to the angiotensin II (Ang II)-induced podocyte injury. Caveolin-1 has been demonstrated to play a crucial role in signaling transduction. In the present study, we evaluated the role of caveolin-1 in ...

journal_title：Cellular signalling

authors： Ren Z,Liang W,Chen C,Yang H,Singhal PC,Ding G

更新日期：2012-02-01 00:00:00

abstract：:Alzheimer's disease (AD) is a neurodegenerative illness and the leading cause of dementia in the elderly. The accumulation of amyloid-β peptide (Aβ) is a well-known pathological hallmark associated with the disease. However, Aβ is only one of several metabolites produced by β- and γ-secretase actions on the transmembr...

journal_title：Cellular signalling

authors： Beckett C,Nalivaeva NN,Belyaev ND,Turner AJ

更新日期：2012-02-01 00:00:00

abstract：:Growing evidence shows that chronic inflammation drives the progression of colorectal cancer (CRC). Cyclooxygenase-2 (COX-2) is one of the most important inflammatory genes involved in solid tumor metastasis. Epidermal growth factor receptor (EGFR) also plays a key role in cancer cell development. We compared the expr...

journal_title：Cellular signalling

authors： Wang JY,Chen BK,Wang YS,Tsai YT,Chen WC,Chang WC,Hou MF,Wu YC,Chang WC

更新日期：2012-01-01 00:00:00

abstract：:Heterotrimeric G proteins typically transduce signals from G protein-coupled receptors (GPCRs) to effector proteins. In the conventional G protein signaling paradigm, the G protein is located at the cytoplasmic surface of the plasma membrane, where, after activation by an agonist-bound GPCR, the GTP-bound Gα and free ...

journal_title：Cellular signalling

authors： Hewavitharana T,Wedegaertner PB

更新日期：2012-01-01 00:00:00

abstract：:The maintenance of muscle mass is critical for health and issues associated with the quality of life. Over the last decade, extensive progress has been made with regard to our understanding of the molecules that regulate skeletal muscle mass. Not surprisingly, many of these molecules are intimately involved in the reg...

journal_title：Cellular signalling

authors： Goodman CA,Mayhew DL,Hornberger TA

更新日期：2011-12-01 00:00:00

abstract：:Single disseminated tumor cells (DTC) can be detected in the bone marrow (BM) from 20% to 60% of patients with various tumors including non-small cell lung cancer (NSCLC). Detection of DTC in the BM of NSCLC patients is associated with poor prognosis and may be responsible for metastatic relapse. However, the function...

journal_title：Cellular signalling

authors： Grabinski N,Bartkowiak K,Grupp K,Brandt B,Pantel K,Jücker M

更新日期：2011-12-01 00:00:00

abstract：:In more than 90% of cancers including glioma, telomere elongation reverse transcriptase (hTERT) is overexpressed. In the present study, we sought to explore whether matrix metalloproteinase-9 (MMP-9) shRNA could alter hTERT-mediated proliferation in glioma cells. MMP-9 shRNA induced senescence and apoptosis in glioma ...

journal_title：Cellular signalling

authors： Ponnala S,Chetty C,Veeravalli KK,Dinh DH,Klopfenstein JD,Rao JS

更新日期：2011-12-01 00:00:00

abstract：BACKGROUND:All identified mammalian TRPC channels show a C-terminal calmodulin (CaM)- and inositol 1,4,5-trisphosphate receptors (IP(3)Rs)-binding (CIRB) site involved in the regulation of TRPC channel function. OBJECTIVES:To assess the basis of CaM/IP(3)Rs binding to the CIRB site of TRPC6 and its role in platelet ph...

journal_title：Cellular signalling

authors： Dionisio N,Albarran L,Berna-Erro A,Hernandez-Cruz JM,Salido GM,Rosado JA

更新日期：2011-11-01 00:00:00

abstract：:Nuclear factor of activated T cells (NFATs) are crucial transcription factors that tightly control proinflammatory cytokine expression for adaptive immunity in T and B lymphocytes. However, little is known about the role of NFATs for innate immunity in macrophages. In this study, we report that NFAT is required for To...

journal_title：Cellular signalling

authors： Minematsu H,Shin MJ,Celil Aydemir AB,Kim KO,Nizami SA,Chung GJ,Lee FY

更新日期：2011-11-01 00:00:00

abstract：:Akt (also known as protein kinase B or PKB) comprises three closely related isoforms Akt1, Akt2 and Akt3 (or PKBα/β/γ respectively). We have a very good understanding of the mechanisms by which Akt isoforms are activated by growth factors and other extracellular stimuli as well as by oncogenic mutations in key upstrea...

journal_title：Cellular signalling

authors： Hers I,Vincent EE,Tavaré JM

更新日期：2011-10-01 00:00:00

abstract：:The present study was designed to investigate (i) the role of AMPK activation in inducing autophagy in androgen-dependent prostate cancer cells subjected to androgen deprivation and hypoxia, and (ii) whether autophagy offers a survival advantage under these harsh conditions. Low androgen and low oxygen are two co-exis...

journal_title：Cellular signalling

authors： Chhipa RR,Wu Y,Ip C

更新日期：2011-09-01 00:00:00

abstract：:Signal transducer and activator of transcription 1 (STAT1) is an important mediator for cytokine signal transduction, particularly IFN-γ. Following IFN-γ stimulation, STAT1 is activated through tyrosine phosphorylation. Little is known about the function and regulation of STAT1 dephosphorylation after activation. We s...

journal_title：Cellular signalling

authors： Chen Z,Ma X,Zhang H,Sun X,Shen S,Li Y,Gu Y,Wang Y,Yan S,Yu Q

更新日期：2011-08-01 00:00:00

abstract：:Phospholipase D (PLD) is involved in diverse cellular processes including cell movement, adhesion, and vesicle trafficking through cytoskeletal rearrangements. However, the mechanism by which PLD induces cytoskeletal reorganization is still not fully understood. Here, we describe a new link to cytoskeletal changes tha...

journal_title：Cellular signalling

authors： Jeon H,Kwak D,Noh J,Lee MN,Lee CS,Suh PG,Ryu SH

更新日期：2011-08-01 00:00:00

abstract：:S6K1, a critical downstream substrate of mTORC1, has been implicated in regulating protein synthesis and a variety of processes that impinge upon cell growth and proliferation. While the role of the cytoplasmic p70(S6K1) isoform in the regulation of translation has been intensively studied, the targets and function of...

journal_title：Cellular signalling

authors： Jastrzebski K,Hannan KM,House CM,Hung SS,Pearson RB,Hannan RD

更新日期：2011-08-01 00:00:00

abstract：:The Integrin-mediated cell adhesion to the extracellular matrix is implicated in the control of proliferation, survival, migration and differentiation of myoblasts. Focal adhesion kinase (FAK) mediates signals from Integrins and plays an essential role in myotube formation. Cdo forms a multiprotein complex that includ...

journal_title：Cellular signalling

authors： Han JW,Lee HJ,Bae GU,Kang JS

更新日期：2011-07-01 00:00:00

abstract：:CyrA is a novel cysteine-rich protein with four EGFL repeats that was isolated using the calmodulin (CaM) binding overlay technique (CaMBOT), suggesting it is a CaM-binding protein (CaMBP). The full-length 63kDa cyrA is cleaved into two major C-terminal fragments, cyrA-C45 and cyrA-C40. A putative CaM-binding domain w...

journal_title：Cellular signalling

authors： Suarez A,Huber RJ,Myre MA,O'Day DH

更新日期：2011-07-01 00:00:00

abstract：:Rho guanosine triphosphatases (GTPases) are a family of small proteins which function as molecular switches in a variety of signaling pathways following stimulation of cell surface receptors. RhoGTPases regulate numerous cellular processes including cytoskeleton organization, gene transcription, cell proliferation, mi...

journal_title：Cellular signalling

authors： Lazer G,Katzav S

更新日期：2011-06-01 00:00:00

abstract：:Although endoplasmic reticulum (ER) stress induction by some anticancer drugs can lead to apoptotic death of cancer cells, combination therapy with other chemicals would be much more efficient. It has been reported that proteasome inhibitors could induce cancer cell death through ER-stress. Our study, however, showed ...

journal_title：Cellular signalling

authors： Huong PT,Moon DO,Kim SO,Kim KE,Jeong SJ,Lee KW,Lee KS,Jang JH,Erikson RL,Ahn JS,Kim BY

更新日期：2011-05-01 00:00:00

abstract：:MAPK signalling is a complex process not only requiring the core components Raf, MEK and Erk, but also many proteins like the scaffold protein KSR and several kinases to specifically localize, modulate and fine-tune the outcome of the pathway in a cell context specific manner. In mammals, protein kinase CK2 was shown ...

journal_title：Cellular signalling

authors： Stark F,Pfannstiel J,Klaiber I,Raabe T

更新日期：2011-05-01 00:00:00

abstract：:The extracellular-regulated kinase (ERK1/2) is a key conduit for transduction of signals from growth factor receptors to the nucleus. Previous work has shown that ERK1/2 activation in response to IGF-1 may require the participation of G proteins, but the role of the receptor tyrosine kinase in this process has not bee...

journal_title：Cellular signalling

authors： Perrault R,Wright B,Storie B,Hatherell A,Zahradka P

更新日期：2011-04-01 00:00:00